A team of scientists from the University of Washington’s Virology Research Clinic in Seattle have confirmed that genital herpes can reactivate even if an infected person undergoes high dose antiviral therapy.
Their findings was based on three trials that involved 113 patients who received antiviral therapy to treat genital herpes, or herpes simplex virus type 2 (HSV—2). More explanation from WebMD:
In the first study, the volunteers were randomly given a standard 400 mg, twice-daily dose of acyclovir or an inactive placebo pill for four weeks. After a one-week washout period, they switched to the active or placebo treatment for another four weeks.
The result: Swabs were 95% less likely to test positive for HSV-2 when a person was taking acyclovir. But even during treatment, people tested positive 3% of the time.
In the second and third studies, the researchers selected volunteers who suffered frequent genital herpes outbreaks. In study two, they took either 800 mg three-a-day, high-dose acyclovir or standard 500 mg daily doses of valacyclovir. Study three compared standard-dose valacyclovir against high-dose valacyclovir (1,000 mg three times daily). As in the first study, volunteers switched treatments after a one-week washout period.
The result: None of these very high doses of active anti-herpes drugs completely prevented genital shedding of infectious herpes virus. Even with high-dose valacyclovir, 3% of swabs carried herpes virus -- and patients tested positive 7% of the time.
The researchers believe that this discovery highlights the need for a new class of treatments to combat this common infection, which affects one in five people.
There are detrimental consequences that come with sleeping on a wrong mattress. It is due to this that all mattress manufacturers usually give out warranties as well as the expected lifespan of their mattress, beyond which the mattress should never be used. If you are having back problems or back pains, then you know what it means to stay comfortable when seated, and most importantly, when sleeping. Read more
If living a healthy lifestyle was easy we’d all be doing it without any problem. The issue is that it’s difficult to change your ways and make modifications when you’re busy and have other responsibilities to take care of.What you need are simple strategies that are going to help you live a healthier lifestyle and experience more satisfaction overall. It’s possible to do so with the right tools and attitude in place, so don’t give up on yourself before you at least try to adjust your behaviors. Get excited about how great you could feel if you merely pay more attention to how you’re living on a regular basis. Read more
Bodybuilding programs can be quite awkward especially when they don't seem to yield results. Perhaps, you lift weights very often and engage in several other bodybuilding exercises but fail to get enough muscle gain in return for the invested effort and time. If you are one of such people who have little to show for all the workouts, you can check out these 5 bodybuilding tips that will give you faster results. Read more